Efficiently cleaved HIV-1 envelopes: can they be important for vaccine immunogen development?
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چکیده
منابع مشابه
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The sole envelope glycoprotein spike on the surface of Human Immunodeficiency Virus (HIV-1) is composed of two subunits: gp120 and gp41. The gp120 consists of three domains: the inner domain, outer domain and bridging sheet, to which the viral primary receptor CD4 binds and induces a conformational change in gp120 to expose the co-receptor binding site. Previous studies have found that the oute...
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BACKGROUND The generation of new immunogens able to elicit strong specific immune responses remains a major challenge in the attempts to obtain a prophylactic or therapeutic vaccine against HIV/AIDS. We designed and constructed a defective recombinant virus based on the HIV-1 genome generating infective but non-replicative virions able to elicit broad and strong cellular immune responses in HIV...
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ژورنال
عنوان ژورنال: Therapeutic Advances in Vaccines and Immunotherapy
سال: 2020
ISSN: 2515-1355,2515-1363
DOI: 10.1177/2515135520957763